The 'Beowulf' actress reportedly went "berserk" when she found out Brad's mother Jane had invited his ex-wife to her home in Missouri for the annual US holiday on November 22.
Jolie has branded their continued friendship "sick" and "sneaky".
A source claims that when Angelina learned of the invitation she screamed at Brad: "That's it then, we'll be staying in Los Angeles. It's all so cozy it's sick."
The source added to Britain's Star magazine: "When she found out, Angelina went berserk. She thinks Jane is keeping up what she calls a sneaky relationship with Jennifer.
"She has pulled no punches, and has made it clear to Brad that there will be no family harmony while Jane keeps up her friendship with Jen.
"But Brad has told Angelina that what his mother does in her own free time is her own business."
Jane and Angelina are reported to have had a furious bust-up over the phone which was caused by a recent interview in which Angelina talked candidly about her drug use, saying: "In the past I took just every drug possible, coke, ecstasy, heroin, everything."
Jane allegedly accused the Tomb Raider star of failing to consider Brad and their children - 17-month biological old daughter Shiloh and adopted kids Zahara, two, Pax, three, and Maddox, six.
Jennifer and Brad's marriage ended in 2005, but she has remained close with her former mother-in-law.
The former 'Friends' star even spent last Thanksgiving with the Pitt family.
A source said: "Jennifer sees no reason to stop being close to Jane. They speak on the phone at least once a month and exchange cards and emails. But, apparently, it makes Angelina's skin crawl."
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